Cell & Gene Therapy
MSC Therapy
UC-MSC treating Liver Cirrhosis
Prof. Nguyen Thanh Liem
Umbilical Cord-derived Mesenchymal Stem Cell Infusion in the Management of Adult Liver Cirrhosis
To evaluate the safety and preliminary efficacy of allogeneic umbilical cord-derived MSCs (UC-MSCs) administered via hepatic artery infusion in patients with liver cirrhosis
Autologous AD-MSC treating Hormone Deficiency in middle ages
Prof. Nguyen Thanh Liem
Evaluation of Autologous Adipose Derived Mesenchymal Stem Cells (AD-MSCs) Therapy on Sexual Hormone Deficiency in the Middle-aged Patients: an Open-label, Single-group Clinical Trial
Phase I: UC-MSC treatment bronchopulmonary dysplasia
Prof. Nguyen Thanh Liem & Dr. Trieu Thi Hong Thai
Outcomes of human umbilical cord-derived mesenchymal stem cell infusion in the treatment of bronchopulmonary dysplasia: phase 1 open-label clinical trial
Autologous BM-MSC therapy combining Psychological education treating Autism
Prof. Nguyen Thanh Liem
Autologous Bone Marrow Stem Cell Therapy Combined With Psychological Therapy and Rehabilitation for Autism: An Open Label Controlled Clinical Trial
Controlled clinical: UC-MSC treating ischemic stroke
Prof. Nguyen Thanh Liem & Dr. Phung Nam Lam
Outcomes of umbilical cord blood-derived mesenchymal stem cell infusion in the treatment of neurological sequelae after ischemic stroke: A controlled clinical trial
Phase I/II: Allogenic UC-MSC treating COPD
Ass Prof. Nguyen Hai Anh & Dr. Hoang Minh Duc
Outcomes of safety and efficacy of allogeneic human umbilical cord-derived mesenchymal stem/stromal cells for chronic obstructive pulmonary disease (COPD): a matched case–control, phase I/II trial
Randomized controlled clinical: VICELL 1 treating frailty
Prof. Nguyen Thanh Liem
Evaluation of the safety and efficacy of umbilical cord-derived mesenchymal stem cell transplantation (VICELL 1) in the treatment of frailty syndrome in the elderly: A randomized controlled clinical trial
To evaluate the effectiveness of intrathecal autologous bone marrow mononuclear cell (BMMNC) therapy combined with education compared with education alone for the treatment of autism spectrum disorder (ASD).
Phase I: AD-MSC (GXIPC1) treating type I diabetes
Prof. Nguyen Thanh Liem & Ass.Prof. Nguyen Thi Hoan
Phase I open-label clinical trial to evaluate safety of adipose-derived mesenchymal stem Cell (GXIPC1) transplantation for type 1 diabetes treatment
Phase I/IIa: UC-MSC treating male Sexual Deficiency
Dr. Nguyen Thi Tan Sinh & Dr. Hoang Thanh Van
Evaluation of the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cell (VCELL 1) for Male Patients With Sexual Deficiency: A Phase I/IIa Randomised Crossover Trial
Autologous AD-MSC treating Female Sexual Deficiency
Dr. Nguyen Thi Tan Sinh & Prof. Nguyen Thanh Liem
Evaluation of Autologous Adipose Tissue-derived Mesenchymal Stem Cell Efficacy for the Treatment of Sexual Function Impairment in Female
CAR-T Therapy
CAR T-Cell Therapy for Leukemia and Lymphoma
PI: Prof. Nguyen Thanh Liem Co-PI: Prof. Nguyen Van Dinh
This Phase I clinical trial aims to evaluate the safety and efficacy of single-dose anti-CD19 CAR T-cell therapy in patients with relapsed or refractory CD19+ non-Hodgkin lymphoma and acute lymphoblastic leukemia
CAR T-Cell Therapy for Lupus Treatment
PI: Prof. Nguyen Thanh Liem Co-PI: Prof. Hoang Thanh Van
This new project aims to develop a potentially curative treatment for lupus, offering patients long-term remission without continuous immunosuppression.
Gene Therapy
Development of genetic testing for cardiovascular diseases
Dr. Dao Thi Mai Lan
Identify the genetic variants cause of cardiovascular diseases by whole exome sequencing and developing and benchmarking the whole exome test for clinical diagnosis of inherited cardiovascular diseases.
Development of genetic testing for drug-resistent epilepsy
Dr. Dao Thi Mai Lan
Identify the genetic variations in pediatric patients with drug resistance epilepsy and Developing and benchmarking the whole exome test for clinical diagnosis of drug resistance epilepsy
Edited-CD34+ cells for treatment of Beta thalassemia
PI:Dr. Dao Thi Mai Lan Co-PI: Dr. Bach Quoc Khanh
Automated generation of CRISPR-Cas9 gene-edited CD34+ cells for clinical treatment of Beta thalassemia (VINIF.DA139)
To research and apply gene-editing technology in combination with an automated cell manufacturing system to edit hematopoietic stem cells from patients with beta thalassemia, meeting required standards and establishing a foundation for the implementation of clinical trials and the development of gene therapy in Vietnam.
Other Cell & Gene therapies
Matched case-control: Autologous BM-MSC treating neurological sequelae post TBI
Prof. Nguyen Thanh Liem
Outcomes of safety and efficacy of autologous bone marrow mononuclear cell infusion in the treatment of neurological sequelae after traumatic brain injury: matched case-control clinical trial
To evaluate the safety and efficacy of autologous bone marrow mononuclear cell administration in treating neurological sequelae after traumatic brain injury
Phase II: Autologous BM-MSC combining Rehabilitation for children with cerebral palsy
Prof Nguyen Thanh Liem
Autologous Bone Marrow Mononuclear Cell Transplantation Combined With Rehabilitation Intervention for children with cerebral Palsy (CP): A phase 2 Randomised Controlled trial
A randomized clinical trial in 58 patients comparing intrathecal autologous bone marrow mononuclear cell infusion combined with rehabilitation with a control group. Group A receives infusions at baseline and after 6 months, while Group B serves as the control for 9 months and then receives infusions at months 9 and 15, with follow up until 18 months.