Dao Thi Mai Lan, PhD
Vinmec Research Institute of Stem Cell and Gene Technology
Gene Technology Specialist
Biography
Dr. Dao Thi Mai Lan received her B.S. degree in Biology from Hanoi University of Science, Vietnam, in 2009, her M.S. degree in Molecular Medicine from Gachon University, Republic of Korea, in 2011, and her Ph.D. degree in Genomics and Bioinformatics from Aix-Marseille University, France, in 2016.
After completing her doctoral studies, she returned to Vietnam and has been working as a gene technology specialist at the Vinmec Research Institute of Stem Cell and Gene Technology (VRISG) since 2017.
Her research focuses on gene therapy for beta-thalassemia and other genetic disorders, CAR-T cell therapy for hematological cancers and autoimmune diseases, and stem cell–based therapies for age-related diseases and regenerative medicine.
Dr. Dao has authored and co-authored numerous publications in high-impact scientific journals and has served as a Guest Editor for Frontiers in Genetics. She is currently a member of the Scientific Research Board of VRISG and serves as Head of the Financial Board of the Vietnam Association of Regenerative Medicine and Cell Therapy (VARC).
Gene therapy for beta thalassemia
CAR T therapy
Mesenchymal stem cell therapy
Cell therapy for aged-related diseases
Molecular biology
Cell biology
Molecular biomedicine
Biomedicine technology
(1) Liem, N. T.; Dao, L. T. M. Cell Therapy for Liver Cirrhosis. In Cell Therapy: Stem Cells and Regenerative Medicine; Liem, N. T., Forsyth, N. R., Heke, M., Eds.; Springer Nature: Singapore, 2025; pp 217–228. https://doi.org/10.1007/978-981-96-1261-1_13.
(2) Nguyen, L. T.; Nguyen, P. M.; Nguyen, H.-P.; Bui, H. T.; Dao, L. T. M.; Van Pham, M.; Hoang, C. K.; Nguyen, P. T.; Nguyen, T. T. P.; Nguyen, A. T. P.; Hoang, V. T.; Bui, H. T. P.; Vuong, N. K.; Van Ngo, D. Outcomes of Autologous Bone Marrow Mononuclear Cell Administration Combined with Educational Intervention in the Treatment of Autism Spectrum Disorder: A Randomized, Open-Label, Controlled Phase II Clinical Trial. Stem Cell Res. Ther. 2025, 16 (1), 268. https://doi.org/10.1186/s13287-025-04404-4.
(3) Hoang, V. T.; Nguyen, Q. T.; Phan, T. T. K.; Pham, T. H.; Dinh, N. T. H.; Anh, L. P. H.; Dao, L. T. M.; Bui, V. D.; Dao, H.; Le, D. S.; Ngo, A. T. L.; Le, Q.; Nguyen Thanh, L. Tissue Engineering and Regenerative Medicine: Perspectives and Challenges. MedComm 2025, 6 (5), e70192. https://doi.org/10.1002/mco2.70192.
(4) Dao, L. T. M.; Vu, T. T.; Nguyen, Q. T.; Hoang, V. T.; Nguyen, T. L. Current Cell Therapies for Systemic Lupus Erythematosus. Stem Cells Transl. Med. 2024, szae044. https://doi.org/10.1093/stcltm/szae044.
(5) Hussain, S.; Sadouni, N.; van Essen, D.; Dao, L. T. M.; Ferré, Q.; Charbonnier, G.; Torres, M.; Gallardo, F.; Lecellier, C.-H.; Sexton, T.; Saccani, S.; Spicuglia, S. Short Tandem Repeats Are Important Contributors to Silencer Elements in T Cells. Nucleic Acids Res. 2023, gkad187. https://doi.org/10.1093/nar/gkad187.
(6) Le, D.-H.; Nguyen, Q.-H.; Dao, L. T. M. Editorial: Computational and Experimental Approaches in Exploring the Role of Genetics and Genomics in Multifactorial Diseases. Front. Genet. 2022, 13.
(7) Hoang, D. M.; Nguyen, K. T.; Hoang, V. T.; Dao, L. T. M.; Bui, H. T.; Ho, T. T. K.; Nguyen, T. T. P.; Ngo, A. T. L.; Nguyen, H. K.; Thanh, L. N. Clinical Study of Mesenchymal Stem/Stromal Cell Therapy for the Treatment of Frailty: A Proposed Experimental Design for Therapeutic and Mechanistic Investigation. J. Gerontol. Ser. A 2021, glab326. https://doi.org/10.1093/gerona/glab326.
(8) Santiago-Algarra, D.; Souaid, C.; Singh, H.; Dao, L. T. M.; Hussain, S.; Medina-Rivera, A.; Ramirez-Navarro, L.; Castro-Mondragon, J. A.; Sadouni, N.; Charbonnier, G.; Spicuglia, S. Epromoters Function as a Hub to Recruit Key Transcription Factors Required for the Inflammatory Response. Nat. Commun. 2021, 12 (1), 6660. https://doi.org/10.1038/s41467-021-26861-0.
(9) Tran, K. T.; Le, V. S.; Dao, L. T. M.; Nguyen, H. K.; Mai, A. K.; Nguyen, H. T.; Ngo, M. D.; Tran, Q. A.; Nguyen, L. T. Novel Findings from Family-Based Exome Sequencing for Children with Biliary Atresia. Sci. Rep. 2021, 11 (1), 21815. https://doi.org/10.1038/s41598-021-01148-y.
(10) Alomairi, J.; Molitor, A. M.; Sadouni, N.; Hussain, S.; Torres, M.; Saadi, W.; Dao, L. T. M.; Charbonnier, G.; Santiago-Algarra, D.; Andrau, J. C.; Puthier, D.; Sexton, T.; Spicuglia, S. Integration of High-Throughput Reporter Assays Identify a Critical Enhancer of the Ikzf1 Gene. PLOS ONE 2020, 15 (5), e0233191. https://doi.org/10.1371/journal.pone.0233191.
(11) Maqbool, M. A.; Pioger, L.; El Aabidine, A. Z.; Karasu, N.; Molitor, A. M.; Dao, L. T. M.; Charbonnier, G.; van Laethem, F.; Fenouil, R.; Koch, F.; Lacaud, G.; Gut, I.; Gut, M.; Amigorena, S.; Joffre, O.; Sexton, T.; Spicuglia, S.; Andrau, J.-C. Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation. Cell Rep. 2020, 32 (7), 108048. https://doi.org/10.1016/j.celrep.2020.108048.
(12) Tran, K. T.; Le, V. S.; Bui, H. T. P.; Do, D. H.; Ly, H. T. T.; Nguyen, H. T.; Dao, L. T. M.; Nguyen, T. H.; Vu, D. M.; Ha, L. T.; Le, H. T. T.; Mukhopadhyay, A.; Nguyen, L. T. Genetic Landscape of Autism Spectrum Disorder in Vietnamese Children. Sci. Rep. 2020, 10 (1), 1–11. https://doi.org/10.1038/s41598-020-61695-8.
(13) Saadi, W.; Kermezli, Y.; Dao, L. T. M.; Mathieu, E.; Santiago-Algarra, D.; Manosalva, I.; Torres, M.; Belhocine, M.; Pradel, L.; Loriod, B.; Aribi, M.; Puthier, D.; Spicuglia, S. A Critical Regulator of Bcl2 Revealed by Systematic Transcript Discovery of lncRNAs Associated with T-Cell Differentiation. Sci. Rep. 2019, 9 (1), 4707. https://doi.org/10.1038/s41598-019-41247-5.
(14) Le, V. S.; Tran, K. T.; Bui, H. T. P.; Le, H. T. T.; Nguyen, C. D.; Do, D. H.; Ly, H. T. T.; Pham, L. T. D.; Dao, L. T. M.; Nguyen, L. T. A Vietnamese Human Genetic Variation Database. Human Mutation. https://doi.org/10.1002/humu.23835.
(15) Le, T. T. H.; Tran, N. T.; Dao, T. M. L.; Nguyen, D. D.; Do, H. D.; Ha, T. L.; Kühn, R.; Nguyen, T. L.; Rajewsky, K.; Chu, V. T. Efficient and Precise CRISPR/Cas9-Mediated MECP2 Modifications in Human-Induced Pluripotent Stem Cells. Front. Genet. 2019, 10. https://doi.org/10.3389/fgene.2019.00625.
(16) Le, D.-H.; Dao, L. T. M. Annotating Diseases Using Human Phenotype Ontology Improves Prediction of Disease-Associated Long Non-Coding RNAs. J. Mol. Biol. 2018. https://doi.org/10.1016/j.jmb.2018.05.006.
(17) Dao, L. T. M.; Spicuglia, S. Transcriptional Regulation by Promoters with Enhancer Function. Transcription 2018, 0 (0), 1–8. https://doi.org/10.1080/21541264.2018.1486150.
(18) Santiago-Algarra, D.; Dao, L. T. M.; Pradel, L.; Espa?a, A.; Spicuglia, S. Recent Advances in High-Throughput Approaches to Dissect Enhancer Function. F1000Research 2017, 6, 939. https://doi.org/10.12688/f1000research.11581.1.
(19) Dao, L. T. M.; Galindo-Albarrán, A. O.; Castro-Mondragon, J. A.; Andrieu-Soler, C.; Medina-Rivera, A.; Souaid, C.; Charbonnier, G.; Griffon, A.; Vanhille, L.; Stephen, T.; Alomairi, J.; Martin, D.; Torres, M.; Fernandez, N.; Soler, E.; van Helden, J.; Puthier, D.; Spicuglia, S. Genome-Wide Characterization of Mammalian Promoters with Distal Enhancer Functions. Nat. Genet. 2017. https://doi.org/10.1038/ng.3884.
(20) Vanhille, L.; Griffon, A.; Maqbool, M. A.; Zacarias-Cabeza, J.; Dao, L. T. M.; Fernandez, N.; Ballester, B.; Andrau, J. C.; Spicuglia, S. High-Throughput and Quantitative Assessment of Enhancer Activity in Mammals by CapStarr-Seq. Nat. Commun. 2015, 6, 6905. https://doi.org/10.1038/ncomms7905.
(21) Mathieu, È.-L.; Belhocine, M.; Dao, L. T. M.; Puthier, D.; Spicuglia, S. Rôle Des Longs ARN Non Codants Dans Le Développement Normal et Pathologique. médecine/sciences 2014, 30 (8–9), 790–796. https://doi.org/10.1051/medsci/20143008018.
(22) Dao, L. T. M.; Park, E.-Y.; Lim, S.-M.; Choi, Y.-S.; Jung, H. S.; Jun, H.-S. Transplantation of Insulin-Producing Cells Differentiated from Human Periosteum-Derived Progenitor Cells Ameliorate Hyperglycemia in Diabetic Mice: Transplantation 2014, 98 (10), 1040–1047. https://doi.org/10.1097/TP.0000000000000388.
(23) Jun, H.-S.; Dao, L. T. M.; Pyun, J.-C.; Cho, S. Effect of Cell Senescence on the Impedance Measurement of Adipose Tissue-Derived Stem Cells. Enzyme Microb. Technol. 2013, 53 (5), 302–306. https://doi.org/10.1016/j.enzmictec.2013.07.001.
(24) Dao, L. T. M.; Park, E.-Y.; Hwang, O.-K.; Cha, J.-Y.; Jun, H.-S. Differentiation Potential and Profile of Nuclear Receptor Expression During Expanded Culture of Human Adipose Tissue-Derived Stem Cells Reveals PPARγ as an Important Regulator of Oct4 Expression. Stem Cells Dev. 2013, 23 (1), 24–33. https://doi.org/10.1089/scd.2013.0137.
(25) Jun, H.-S.; Dao, L. T. M.; Cho, S. Electrical Impedance Detection of Senescence in Adipose Tissue-Derived Stem Cells. Procedia Eng. 2012, 47, 1025–1028. https://doi.org/10.1016/j.proeng.2012.09.323.
(26) Nguyen HP, Dao LTM, Le Phuong Hoang A, Nguyen TST, Uy SRC, Nguyen TH, et al. Prevalence of and risk factors for female sexual dysfunction in middle-aged Vietnamese women: A cross-sectional hospital-based study. Maturitas. 2025;202:108743.
2009: Bachelor in Biology, Hanoi University of Science, Vietnam
2011: Master in Molecular Medicine, Gachon University, South of Korea
2016: PhD in Genomics and Bioinformatics Aix-Marseille University, France
2012: The full scholarship for PhD from Vietnam International Education Development
2009: The full scholarship for Master from Gachon University of Medicine and Science, South of Korea
2008: The Typical Young Figure from Vietnam National University, Vietnam
2008” The honorable scholarship from Bank of Tokyo-Mitsubishi UFJ Scholarship, Japan
2007: The “VALLET” scholarship from “Rencontres du Vietnam” Organization, France
2005: The 3rd Prize of National Biology Contest for high school students, Vietnam