Van T. Hoang, PhD
Research Insitute of Stem Cell and Gene Therapy
Head of the Clinical Applied Research Department
Biography
Dr. Van T. Hoang is an Assistant Professor at the College of Health Sciences, VinUniversity, and Head of the Clinical Applied Research Department at the Vinmec Research Institute of Stem Cell and Gene Technology, VinUniversity. She earned her Diplom degree in cell biology, molecular biology, and biochemistry from the University of Heidelberg in 2009, and completed her PhD in biomedicine in 2014. From 2014 to 2016, she was a Postdoctoral Researcher at the Medical Department of the University of Heidelberg, followed by a position at Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, from 2016 to 2018 in Germany. Since 2018, Dr. Hoang has been a scientist at the Vinmec Institute of Stem Cell and Gene Technology. Her research focuses on translational approaches involving mesenchymal stem/stromal cell therapy and the therapeutic applications of extracellular vesicles to address unmet medical needs. She led the CAR T-cell laboratory team that established the first point-of-care CAR T-cell manufacturing program in Vietnam. Beyond her research, Dr. Hoang is a founding member and currently serves as Deputy General Secretary of the Vietnam Association of Regenerative Medicine and Cell Therapy (VARC). She has also been a guest lecturer at Vietnam National University since 2020.
Cell therapy
CAR-T cell research
Stem cell research
Mesenchymal stem cell therapy
Extracellular versicle therapy
Cancer
Cell biology
Stem cell
Clinical research
1. Dang, V. D., Szelinski, F., Mohr, E., Le, T. A., Ritter, J., Wiedemann, A., Ferreira-Gomes, M., Guerra, G. M., Durek, P., Heinrich, F., Rincon-Arevalo, H., Stefanski, A. L., Schrezenmeier, E., Hoang, V. T., Dao, H. N., Ocvirk, S., Cheng, Q., Hiepe, F., Hipfl, C., . . . Lino, A. C. (2025). Distinct autoreactive CD19(-) plasma cell subsets accumulate in lupus-prone mice. Nature Communications, 16(1), 9901. https://doi.org/10.1038/s41467-025-65906-6
2. Dinh, N. T., Nguyen, Q. T., Hang, N. T., Dao, H. N., Son, L. D., Ngan, G. T., Mao, C. V., Do, X. H., Hoang, V. T. #, & Thanh, L. N. (2025). Assessment of the safety of hypoxia-primed mesenchymal stem cells derived from umbilical cord and adipose tissues in animals. Scientific Reports, 15(1), 36055. https://doi.org/10.1038/s41598-025-20018-5
3. Nguyen, L. T., Nguyen, P. M., Nguyen, H. P., Bui, H. T., Dao, L. T. M., Van Pham, M., Hoang, C. K., Nguyen, P. T., Nguyen, T. T. P., Nguyen, A. T. P., Hoang, V. T., Bui, H. T. P., Vuong, N. K., & Van Ngo, D. (2025). Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial. Stem Cell Research & Therapy, 16(1), 268. https://doi.org/10.1186/s13287-025-04404-4
4. Nguyen, L. T., Nguyen, T. T. N., Nguyen, K. T., Phung, L. N., Hoang, V. T., Phan, T. T. K., Van Pham, M., Nguyen, A. T. P., Van Ngo, D., Van Nguyen, A., & Van Nguyen, C. (2025). Intrathecal versus intravenous umbilical cord mesenchymal stem cells for ischemic stroke sequelae. STEM CELLS Translational Medicine, 14(12). https://doi.org/10.1093/stcltm/szaf063
5. Nguyen, L. T., Thi Huong Ha, G., Trung Nguyen, K., Thanh Hoang, V., Thi Nguyen, Q., Van Pham, M., Thi Phuong Nguyen, A., Van Ngo, D., Thu Le, H., & Van Nguyen, C. (2025). Autologous bone marrow mononuclear cell administration for neurological sequelae after traumatic brain injury: a matched control study. Brain Commun, 7(5), fcaf361. https://doi.org/10.1093/braincomms/fcaf361
6. Nguyen, Q. T., Dinh, N. T. H., Hang, N. T., Van Mao, C., Do, X. H., Le, D. S., Dao, H. N., Giang, T. N., Forsyth, N., Hoang, V. T. #, & Thanh, L. N. (2025). Safety evaluation of extracellular vesicles derived from hypoxia primed mesenchymal stem cells of umbilical cord and adipose tissue. Scientific Reports, 15(1), 36267. https://doi.org/10.1038/s41598-025-20121-7
7. Hoang, V. T. *,#, Nguyen, Q. T., Phan, T. T. K., Pham, T. H., Dinh, N. T. H., Anh, L. P. H., Dao, L. T. M., Bui, V. D., Dao, H.-N., Le, D. S., Ngo, A. T. L., Le, Q.-D., & Nguyen Thanh, L. (2025). Tissue Engineering and Regenerative Medicine: Perspectives and Challenges. MedComm, 6(5), e70192. https://doi.org/https://doi.org/10.1002/mco2.70192
8. Hoang, V. T.*,#; Duc Son Le*; Duc M. Hoang; Trang Thi Kieu Phan; Lan Anh Thi Ngo; Trung Kien Nguyen; Viet Anh Bui; Liem Nguyen Thanh# (2024). Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma. Stem Cell Research & Therapy, 15(1), 56. https://doi.org/10.1186/s13287-023-03582-3
9. Dao, L. T. M., Vu, T. T., Nguyen, Q. T., Hoang, V. T., & Nguyen, T. L. (2024). Current cell therapies for systemic lupus erythematosus. STEM CELLS Translational Medicine, 13(9), 859-872. https://doi.org/10.1093/stcltm/szae044
10. Nguyen, Q. T., Thanh, L. N., Hoang, V. T., Phan, T. T. K., Heke, M., & Hoang, D. M. (2023). Bone Marrow-Derived Mononuclear Cells in the Treatment of Neurological Diseases: Knowns and Unknowns. Cellular and Molecular Neurobiology, 43(7), 3211–3250. https://doi.org/10.1007/s10571-023-01377-x.
11. Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., Heke, M., & Nguyen, L. T. (2022). Stem cell-based therapy for human diseases. Signal Transduction and Targeted Therapy, 7(1), 272. https://doi.org/10.1038/s41392-022-01134-4
12. Hoang, V. T.*, Nguyen, H.-P., Nguyen, V. N., Hoang, D. M., Nguyen, T.-S. T., & Nguyen Thanh, L. (2022). “Adipose-derived mesenchymal stem cell therapy for the management of female sexual dysfunction: Literature reviews and study design of a clinical trial.” Frontiers in Cell and Developmental Biology, 10, 956274. https://doi.org/10.3389/fcell.2022.956274
13. Nguyen Thanh, L.*, Hoang, V. T.*, Le Thu, H., Nguyen, P. A. T., Hoang, D. M., Ngo, D. V., Cao Vu, H., Nguyen Thi Bich, V., & Heke, M. (2022). Human Umbilical Cord Mesenchymal Stem Cells for Severe Neurological Sequelae due to Anti- N -Methyl- D -Aspartate Receptor Encephalitis: First Case Report. Cell Transplantation, 31, 096368972211108. https://doi.org/10.1177/09636897221110876
14. Dam, P. T. M.*, Hoang, V. T.*, Bui, H. T. H., Hang, L. M., Hoang, D. M., Nguyen, H. P., Lien, H. T., Tran, H. T. T., Nguyen, X.-H., & Nguyen Thanh, L.# (2021). Human Adipose-Derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-free and Serum-free Condition. Stem Cell Reviews and Reports.
15. Nguyen, L. T., Hoang, D. M., Nguyen, K. T., Bui, D. M., Nguyen, H. T., Le, H. T. A., Hoang, V. T., Bui, H. T. H., Dam, P. T. M., Hoang, X. T. A., Ngo, A. T. L., Le, H. M., Phung, N. Y., Vu, D. M., Duong, T. T., Nguyen, T. D., Ha, L. T., Bui, H. T. P., Nguyen, H. K., … Bui, A. V. (2021). Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow‐derived mesenchymal stem/stromal cells. STEM CELLS Translational Medicine.
16. Nguyen, M. Q., Bui, H. T. H., Tuyet, A. N. T., Nhung, T. T. H., Hoang, D. M., Liem, N. T., & Hoang, V. T.# (2021). Comparative Bioactivity Analysis for Off-the-Shelf and Culture–Rescued Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells in a Xeno- and Serum-Free Culture System. Cell Transplantation, 30, 096368972110394.
17. Hoang, V. T.*, #, Trinh, Q.-M., Phuong, D. T. M., Bui, H. T. H., Hang, L. M., Ngan, N. T. H., Anh, N. T. T., Nhi, P. Y., Nhung, T. T. H., Lien, H. T., Nguyen, T. D., Thanh, L. N., & Hoang, D. M.# (2020). “”Standardized xeno- and serum-free culture platform enables large-scale expansion of high-quality mesenchymal stem/stromal cells from perinatal and adult tissue sources.”” Cytotherapy.
18. Hoang, V. T.*, D. Verma, P. S. Godavarthy, P. Llavona, M. Steiner, K. Gerlach, B. E. Michels, H. Bohnenberger, A. Wachter, T. Oellerich, U. Muller-Kuller, E. Weissenberger, J. M. Voutsinas, V. G. Oehler, H. F. Farin, M. Zornig and D. S. Krause (2019). The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. Leukemia, 33(7):1700-1712.
19. Wang, W., T. Stiehl, S. Raffel, V. T. Hoang, I. Hoffmann, L. Poisa-Beiro, B. R. Saeed, R. Blume, L. Manta, V. Eckstein, T. Bochtler, P. Wuchter, M. Essers, A. Jauch, A. Trumpp, A. Marciniak-Czochra, A. D. Ho and C. Lutz (2017). Reduced hematopoietic stem cells frequency predicts outcome in acute myeloid leukemia. Haematologica, 102(9):1567-1577.
20. V.T. Hoang*, E. C. Buss, W. Wang, I. Hoffmann, S. Raffel, A. Zepeda-Moreno, N. Baran, P. Wuchter, V. Eckstein, A. Trumpp, A. Jauch, A. D. Ho and C. Lutz (2015). The rarity of ALDH(+) cells is the key to separation of normal versus leukemia stem cells by ALDH activity in AML patients. Int J Cancer, 137(3):525-536.
21. Hanke, M., I. Hoffmann, C. Christophis, M. Schubert, V. T. Hoang, A. Zepeda-Moreno, N. Baran, V. Eckstein, P. Wuchter, A. Rosenhahn and A. D. Ho (2014). Differences between healthy hematopoietic progenitors and leukemia cells with respect to CD44 mediated rolling versus adherence behavior on hyaluronic acid coated surfaces. Biomaterials, 35(5):1411-1419.
22. Lutz, C., V. T. Hoang, E. Buss and A. D. Ho (2013). Identifying leukemia stem cells–is it feasible and does it matter? Cancer Lett, 338(1):10-14.
08/2016-06/2018: Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Germany – Postdoctoral fellow
07/2014-07/2016: Department of Internal Medicine V (Hematology, Oncology and Rheumatology), University Hospital of Heidelberg, Germany – Postdoctoral fellow
12/2009–06/2014: University Hospital of Heidelberg, Germany – PhD
10/2004-12/2009 University of Heidelberg, Germany – Diploma in molecular biology, cell biology and biochemistry
10/2003-10/2004: University of Heidelberg, Germany – Studienkolleg